Studies on Antidiabetic Activity of Indian Medicinal Plants Using -Amylase and -Glucosidase Inhibitory Activity - A Pathway to Antidiabetic Drugs

Diabetes mellitus is a multifactorial disease. The nature has a plentiful sources as a remeady for this slow-killing condition. The aim of the present to assess the medicinal plants for anti-diabetic activity by using -amylase and -glucosidase inhibition assay. Anti-diabeticactivities of medicinal plants weredetermined by -amylase and -glucosidase inhibition assay. Results revealed that methonolic extract of plants posses inhibitory properties of alpha amylase and alpha glucosidase in vitro. The IC of W. 50 somnifera (0.54 mg/ ml), O. sanctum (0.55 mg/ ml) and A. paniculata (0.57 mg / ml) showed equal inhibitory activity with the positive control, acarbose (0.54 mg/ ml). A. calamus (IC -0.3 mg/ ml) showed nearly 50% higher 50 activity than the acarbose in the present study. W. somnifera (0.58 mg/ ml), O. sanctum (0.58 mg/ ml) were lower than the positive control (acarbose, 0.8 mg/ ml) against -glucosidase enzyme (p<0.001). In conclusion, the results indicate that crude extracts of multifarious plant possesses anti-diabetic effect through alpha amylase and alpha glucosidase inhibitory concentration (IC ) and this research conformed the need of further study. 50